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Open AccessJournal ArticleDOI

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

Eisuke Itakura, +2 more
- 07 Dec 2012 - 
- Vol. 151, Iss: 6, pp 1256-1269
TLDR
This work identifies syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome, and reveals a mechanism by which the SNARE protein is available to the completed Autophagosome.
About: 
This article is published in Cell.The article was published on 2012-12-07 and is currently open access. It has received 988 citations till now. The article focuses on the topics: Vesicle fusion & Autophagosome maturation.

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Citations
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Mechanism and medical implications of mammalian autophagy

Ivan Dikic, +1 more
- 01 Jun 2018 - 
TL;DR: It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.
Journal ArticleDOI

The machinery of macroautophagy

Yuchen Feng, +3 more
- 01 Jan 2014 - 
TL;DR: This review focuses on macroautophagy, briefly describing the discovery of this process in mammalian cells, discussing the current views concerning the donor membrane that forms the phagophore, and characterizing the autophagy machinery including the available structural information.
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Autophagy in infection, inflammation and immunity

Vojo Deretic, +2 more
- 01 Oct 2013 - 
TL;DR: As discussed in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.
Journal ArticleDOI

An Overview of Autophagy: Morphology, Mechanism, and Regulation

Katherine R. Parzych, +1 more
- 20 Jan 2014 - 
TL;DR: Current knowledge of the morphology, molecular mechanism, and regulation of mammalian autophagy is described, which will aid in the development of new treatments for human diseases in which autphagy is not functioning properly.
References
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Journal ArticleDOI

Autophagy in the Pathogenesis of Disease

Beth Levine, +3 more
- 11 Jan 2008 - 
TL;DR: This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.
Journal ArticleDOI

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Yukiko Kabeya, +13 more
- 01 Nov 2000 - 
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima, +1 more
- 11 Nov 2011 - 
TL;DR: It is explored how recent mouse models in combination with advances in human genetics are providing key insights into how the impairment or activation of autophagy contributes to pathogenesis of diverse diseases, from neurodegenerative diseases such as Parkinson disease to inflammatory disorders such as Crohn disease.
Journal ArticleDOI

Methods in Mammalian Autophagy Research

Noboru Mizushima, +2 more
- 05 Feb 2010 - 
TL;DR: Methods to monitor autophagy and to modulate autophagic activity are discussed, with a primary focus on mammalian macroautophagy.
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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