Zonda is a novel early component of the autophagy pathway in Drosophila

doi:10.1091/MBC.E16-11-0767

Open AccessJournal ArticleDOI

Zonda is a novel early component of the autophagy pathway in Drosophila

Mariana Melani, +21 more

- 13 Sep 2017 -

Molecular Biology of the Cell

- Vol. 28, Iss: 22, pp 3070-3081

TLDR

Zonda, a novel Drosophila immunophilin, is an early component of the autophagy machinery necessary for Vps34-mediated phosphatidylinositol 3-phosphate deposition prior to omegasome formation.

Abstract:

Fil: Melani, Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires. Fundacion Instituto Leloir. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina

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International Review of Cell and Molecul...

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References

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Elizabeth L. Axe, +8 more

- 25 Aug 2008 -

Journal of Cell Biology

TL;DR: It is shown that double FYVE domain–containing protein 1, a PI(3)P-binding protein with unusual localization on ER and Golgi membranes, translocates in response to amino acid starvation to a punctate compartment partially colocalized with autophagosomal proteins, which may be involved in Autophagosome biogenesis.

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Allan C. Spradling, +1 more

- 22 Oct 1982 -

Science

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