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Journal ArticleDOI

A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture

Andrew J. F. Valente, +4 more
- 01 Apr 2017 - 
- Vol. 119, Iss: 3, pp 315-326
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TLDR
The Mitochondrial Network Analysis (MiNA) toolset is described, a relatively simple pair of macros making use of existing ImageJ plug-ins, allowing for semi-automated analysis of mitochondrial networks in cultured mammalian cells.
About: 
This article is published in Acta Histochemica.The article was published on 2017-04-01. It has received 443 citations till now.

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Amit Joshi, +8 more
- 23 Sep 2019 - 
TL;DR: It is shown that the expression of neurotoxic proteins associated with neurodegenerative diseases in microglia alone is sufficient to directly trigger death of naive neurons and to propagate neuronal death through activation of naive astrocytes to the A1 state, without affecting the release of healthy neuroprotective mitochondria.
Journal ArticleDOI

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells.

Sara Omenetti, +12 more
- 16 Jul 2019 - 
TL;DR: Comparisons of characteristics of Th17 cells differentiating in response to commensal bacteria (SFB) to those differentiating to a pathogen (Citrobacter rodentium) will help ensure that future therapies directed against inflammatory Th 17 cells do not inadvertently damage the resident gut population.
Journal ArticleDOI

Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission

Sukrut C. Kamerkar, +4 more
- 07 Dec 2018 - 
TL;DR: It is demonstrated that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins, and is the dominant dynamin performing mitochondria and per oxisomal fission.
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Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

Marco Tigano, +8 more
- 24 Feb 2021 - 
TL;DR: In this article, the authors show that mtDNA double-strand breaks activate a type-I interferon response that involves the phosphorylation of STAT1 and activation of interferón-stimulated genes.
References
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Journal Article

R: A language and environment for statistical computing.

R Core Team
- 01 Jan 2014 - 
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI

NIH Image to ImageJ: 25 years of image analysis

Caroline A Schneider, +2 more
- 01 Jul 2012 - 
TL;DR: The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.
Journal ArticleDOI

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin, +15 more
- 01 Jul 2012 - 
TL;DR: Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis that facilitates the transformation of new algorithms into ImageJ plugins that can be shared with end users through an integrated update system.
Book

ggplot2: Elegant Graphics for Data Analysis

Hadley Wickham
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
Journal ArticleDOI

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Gilad Twig, +17 more
- 23 Jan 2008 - 
TL;DR: Pulse chase and arrest of autophagy at the pre‐proteolysis stage reveal that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagic.
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Fiji: an open-source platform for biological-image analysis

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- 01 Jul 2012 - 

Mitochondrial fusion and fission in cell life and death

Benedikt Westermann
- 01 Dec 2010 - 

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

Ligia C. Gomes, +2 more
- 01 May 2011 - 

Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.

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- 02 Apr 2013 -