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Open AccessJournal ArticleDOI

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue.

Peng Zhao, +10 more
- 08 Feb 2018 - 
- Vol. 172, Iss: 4, pp 731-743
TLDR
It is reported that the kinase uniquely controls energy metabolism, and a unique role for TBK1 in mediating bidirectional crosstalk between energy sensing and inflammatory signaling pathways in both over- and undernutrition.
About: 
This article is published in Cell.The article was published on 2018-02-08 and is currently open access. It has received 179 citations till now. The article focuses on the topics: AMPK & TANK-binding kinase 1.

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Journal ArticleDOI

Mechanisms of Insulin Action and Insulin Resistance

Max C. Petersen, +1 more
- 01 Oct 2018 - 
TL;DR: This work aims to develop an integrated physiological perspective, placing the intricate signaling effectors that carry out the cell-autonomous response to insulin in the context of the tissue-specific functions that generate the coordinated organismal response.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

Jose Norberto S. Vargas, +10 more
- 18 Apr 2019 - 
TL;DR: This study demonstrates that ectopic placement of NDP52 on mitochondria or peroxisomes is sufficient to initiate selective autophagy by focally localizing and activating the ULK1 complex, and highlights the coordination of ULK 1 complex localization by autophagic receptors and TBK1 as principal drivers of targeted autophagosome biogenesis.
Journal ArticleDOI

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.

Xianjun Luo, +23 more
- 01 Dec 2018 - 
TL;DR: Levels of STing were increased in liver tissues from patients with NAFLD and mice with HFD-induced steatosis and in mice, loss of STING from macrophages decreased the severity of liver fibrosis and the inflammatory response.
Journal ArticleDOI

Autophagy in inflammation, infection, and immunometabolism.

Vojo Deretic
- 09 Mar 2021 - 
TL;DR: In this paper, the role of autophagy in inflammation, including type I interferon responses and inflammasome outputs, from molecules to immune cells is discussed, and a special emphasis is given to the intersections of autoophagy with innate immunity, immunometabolism, and functions of organelles such as mitochondria and lysosomes that act as innate immunity and immunometabolic signaling platforms.
References
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Journal ArticleDOI

Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, +5 more
- 15 Dec 2003 - 
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
Journal ArticleDOI

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

Gökhan S. Hotamisligil, +2 more
- 01 Jan 1993 - 
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.

Haiyan Xu, +10 more
- 15 Dec 2003 - 
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

Zhidan Wu, +10 more
- 09 Jul 1999 - 
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
Related Papers (5)

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Shannon M. Reilly, +21 more
- 01 Mar 2013 - 

The protein kinase IKKepsilon regulates energy balance in obese mice

Shian Huey Chiang, +14 more
- 04 Sep 2009 - 

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

Katherine A. Fitzgerald, +8 more
- 01 May 2003 - 

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

Manohar Pilli, +14 more
- 24 Aug 2012 - 

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

Philipp Wild, +13 more
- 08 Jul 2011 -