Weidong Han

TL;DR: This is the first report to demonstrate that calcium/CaMKIIγ/AKT signaling can regulate apoptosis and autophagy simultaneously in cancer cells, and the combination of the SOCE inhibitor SKF-96365 with autophagic inhibitors represents a promising strategy for treating patients with colorectal cancer.

TL;DR: Findings reveal that, although apoptotic/drug resistance is a formidable "stronghold" of cancer against chemotherapy, necroptotic susceptibility is an intrinsic “weak point” of cancer, therefore, targeting the weakness of cancer by induction of ne croptosis may have significant potential in cancer chemotherapy, especially in the apoptosis/drug resistant cancers.

TL;DR: It is demonstrated, for the first time, that Sal B is a novel autophagy inducer and exerts its antitumor activity as a single agent in colorectal cancer cells through the suppression of AKT/mTOR pathway.

TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis

TL;DR: This study found that CsA significantly augmented the anti-cancer effect of gefitinib in EGFR-TKI-sensitive and -resistant NSCLC cells, and provided preclinical evidence that the combination of CsSA or a STAT3 inhibitor with EG FR-TKIs is a promising approach to improve the efficacy of EGfr- TKIs for the treatment of patients with advanced NSCLCs.