Erik Norberg

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The current knowledge about the molecular mechanisms regulating the processing and release of AIF from the mitochondria will be summarized and discussed in this review.

TL;DR: It is shown that a prolonged (∼10 min) increase in intracellular Ca2+ level is a prerequisite step for AIF processing and release during cell death, andhibition of calpain, or chelation of Ca2+, but not the suppression of caspase activity, preventedprocessing and release of AIF.

TL;DR: It is demonstrated that high levels of exogenously generated H2O2 induce extensive DNA damage, ATP depletion, and severe cytotoxicity, and could-at least in part-be prevented by RIP1 kinase inhibition.

TL;DR: It is proposed that mitochondrially targeted delivery of anti-cancer drugs is enhanced by the addition of a triphenylphosphonium group (TPP(+)), and MitoVES proved superior in suppression of experimental tumors compared to the untargeted analog.