Catherine Andreadi

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Induction of HO-1 by curcumin, EGCG, or low concentrations of helenalin did not protect MDA-MB468 breast cells or B-lymphoblasts from apoptosis, suggesting that signaling through p38 mitogen-activated protein kinase, NF-κB, and Nrf2 as well as other unidentified molecules is involved in HO- 1 induction by hemin and both polyphenols, but cell-specific factors also play a role.

TL;DR: The findings suggest that resveratrol is delivered to target tissues in a stable sulfate-conjugated form and that the parent compound is gradually regenerated in selected cells and may give rise to the beneficial effects in vivo.

TL;DR: It is shown that a low rather than a high dose of resveratrol prevents tumor growth in mice and alters metabolic pathways in human tissues and suggests that it's time for a revision in development strategies for preventative dietary agents.

TL;DR: This review considers the physiologically achievable doses for a few of the best studied agents and summarizes the data derived from studies using these low concentrations in cell culture to conclude that each of the compounds shows an encouraging range of activities in vitro at concentrations which are likely to be physiologically relevant.