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L. Ashley Cowart

Researcher at Medical University of South Carolina

Publications -  62
Citations -  7643

L. Ashley Cowart is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Sphingolipid & Ceramide. The author has an hindex of 30, co-authored 50 publications receiving 6907 citations. Previous affiliations of L. Ashley Cowart include Veterans Health Administration & Virginia Commonwealth University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

Sarah Brice Russo, +6 more
- 01 Nov 2012 - 
TL;DR: A requirement for a specific sphingolipid metabolic route and dietary SFAs in the molecular pathogenesis of lipotoxic cardiomyopathy and hypertrophy is revealed.
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Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

Fernando Alvarez-Vasquez, +6 more
- 27 Jan 2005 - 
TL;DR: Simulations of metabolic fluxes, enzyme deletion and the effects of inositol led to predictions that show significant concordance with experimental results generated post hoc, demonstrating that modelling now allows testable predictions as well as the design and evaluation of hypothetical 'thought experiments' that may generate new metabolomic approaches.
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Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.

Brittany A. Law, +10 more
- 10 Nov 2017 - 
TL;DR: The results support a model by which CerS2 and VLC ceramides have a distinct role in lipotoxicity, leading to mitochondrial damage, which results in subsequent adaptive mitophagy, which causes cell death in cardiomyocytes.
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Yeast sphingolipids: Recent developments in understanding biosynthesis, regulation, and function

L. Ashley Cowart, +2 more
- 01 Mar 2007 - 
TL;DR: Due to many factors including ease of culture and genetic modification, and conservation of major sphingolipid metabolic pathways, Saccharomyces cerevisiae has served as an ideal model system with which to identify enzymes of sphingoipid biosynthesis and to dissect sphingoripid function.