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Open AccessJournal ArticleDOI

Therapeutic Targeting of Autophagy.

Christina G. Towers, +1 more
- 01 Dec 2016 - 
- Vol. 14, pp 15-23
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TLDR
Recent literature implicating autophagy in neurodegenerative diseases and cancer is reviewed to highlight some of the opportunities, controversies and potential pitfalls of therapeutically targeting Autophagy.
About: 
This article is published in EBioMedicine.The article was published on 2016-12-01 and is currently open access. It has received 240 citations till now. The article focuses on the topics: Autophagy.

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Citations
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Mechanism and medical implications of mammalian autophagy

Ivan Dikic, +1 more
- 01 Jun 2018 - 
TL;DR: It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.
Journal ArticleDOI

Targeting autophagy in cancer

Jean M. Mulcahy Levy, +3 more
- 28 Jul 2017 - 
TL;DR: A way forward is suggested for the effective targeting of autophagy by understanding the context-dependent roles of autophile and by capitalizing on modern approaches to clinical trial design.
Journal ArticleDOI

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology.

Eva Schrezenmeier, +1 more
- 07 Feb 2020 - 
TL;DR: Mechanistic data give insights into the immunomodulatory potency of hydroxychloroquine and provide the rationale to search for more potent and/or selective inhibitors in antimalarial drugs.
Journal ArticleDOI

Autophagy in Human Diseases

Noboru Mizushima, +1 more
- 14 Oct 2020 - 
TL;DR: Autophagy in Human Diseases Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles that is associated with certain cancers, neurodeletes, and other diseases.
Journal ArticleDOI

Cytotoxic CD8 + T cells in cancer and cancer immunotherapy

Hans Raskov, +3 more
- 19 Jan 2021 - 
TL;DR: Advances in research on the most prominent immune effectors in cancer and cancer immunotherapy, cytotoxic T cells, are summarized and possible implications for future cancer treatment are discussed.
References
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Journal ArticleDOI

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden, +2 more
- 22 May 2009 - 
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Comprehensive Clinical Nephrology 3rd Edition

M Seziş Demirci
Journal ArticleDOI

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek P. Narendra, +3 more
- 01 Dec 2008 - 
TL;DR: It is shown that Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential in mammalian cells and this recruitment promotes autophagy of damaged mitochondria and implicate a failure to eliminate dysfunctional mitochondira in the pathogenesis of Parkinson's disease.
Journal ArticleDOI

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, +12 more
- 15 Jun 2006 - 
TL;DR: It is found that mice lacking Atg7 specifically in the central nervous system showed behavioural defects, including abnormal limb-clasping reflexes and a reduction in coordinated movement, and died within 28 weeks of birth, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies.
Related Papers (5)

Targeting autophagy in cancer

Jean M. Mulcahy Levy, +3 more
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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- 21 Jan 2016 - 

Comprehensive Clinical Nephrology 3rd Edition

M Seziş Demirci

Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Xiao Huan Liang, +6 more
- 09 Dec 1999 - 

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima, +1 more
- 11 Nov 2011 -