Katja Köhler

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Imaginal morphogenesis protein-Late 2 (Imp-L2) is the first functionally characterized insulin-binding protein in invertebrates and serves as a nutritionally controlled suppressor of insulin-mediated growth in Drosophila.

TL;DR: It is shown that starvation induces autophagy in germline cells (GCs) and in follicle cells (FCs) in Drosophila ovaries and this process is mediated by the ATG machinery and involves the upregulation of Atg genes, and it is demonstrated that insulin/TOR signaling controls autophagic in FCs and GCs.

TL;DR: Genetic epistasis analysis places lnk downstream of the insulin receptor (InR) and upstream of phosphoinositide 3-kinase (PI3K) in the IIS cascade, at the same level as chico (encoding the single fly insulin receptor substrate [IRS] homolog).