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Louis R. Lapierre

Researcher at Brown University

Publications -  36
Citations -  7354

Louis R. Lapierre is an academic researcher from Brown University. The author has contributed to research in topics: Autophagy & Biology. The author has an hindex of 18, co-authored 29 publications receiving 6397 citations. Previous affiliations of Louis R. Lapierre include Sanford-Burnham Institute for Medical Research & Dalhousie University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

TL;DR: It is demonstrated that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan, and a conserved role for HLH -30 and TFEB in autophagy, and possibly longevity is demonstrated.
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Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

TL;DR: A novel mechanism by which autophagy and the lipase LIPL-4 interdependently modulate aging in germline-deficient C. elegans by maintaining lipid homeostasis to prolong life span is offered.
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Transcriptional and epigenetic regulation of autophagy in aging

TL;DR: Current research on epigenetic changes, such as histone modification by the deacetylase SIRT1, that influence autophagy-related gene expression and additionally affect aging are reviewed.
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Lessons from C. elegans: signaling pathways for longevity

TL;DR: Three major endocrine- and nutrient-sensing signaling pathways with influence on lifespan, the insulin/insulin-like growth factor (IGF), target of rapamycin (TOR), and germline signaling pathways are reviewed, with special emphasis on the role of lipid metabolism and autophagy.