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Salvatore Pepe

Researcher at Royal Children's Hospital

Publications -  131
Citations -  10554

Salvatore Pepe is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 39, co-authored 128 publications receiving 9804 citations. Previous affiliations of Salvatore Pepe include University of Adelaide & Alfred Hospital.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

Magdalena Juhaszova, +14 more
- 01 Jun 2004 - 
TL;DR: It is shown that reoxygenation after prolonged hypoxia reduces the reactive oxygen species (ROS) threshold for the mitochondrial permeability transition (MPT) in cardiomyocytes and that cell survival is steeply negatively correlated with the fraction of depolarized mitochondria.
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Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes

Martin Vila Petroff, +6 more
- 01 Oct 2001 - 
TL;DR: It is proposed that myocyte NO produced by activation of the PI(3)K–Akt–endothelial NOS axis acts as a second messenger of stretch by enhancing RyRC activity, contributing to myocardial contractile activation.
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Cardiac Membrane Fatty Acid Composition Modulates Myocardial Oxygen Consumption and Postischemic Recovery of Contractile Function

Salvatore Pepe, +1 more
- 14 May 2002 - 
TL;DR: Dietary fish oil directly influenced heart function and improved cardiac responses to ischemia and reperfusion, and direct effects on myocardial function may contribute to the altered cardiovascular disease profile associated with fish consumption.
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PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH

Salvatore Pepe, +3 more
- 01 Jan 1999 - 
TL;DR: Manipulating the cardiac Mito membrane n-3-to-n-6 PUFA ratio shows that the activation of Ca2+-dependent PDH can be augmented when the n-4 to n-6PUFA ratio is low, or attenuated when this ratio is relatively high (n-3 PUFA-rich diet).