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Thomas Simmet

Researcher at University of Ulm

Publications -  211
Citations -  15559

Thomas Simmet is an academic researcher from University of Ulm. The author has contributed to research in topics: Proinflammatory cytokine & Monocyte. The author has an hindex of 54, co-authored 202 publications receiving 13691 citations. Previous affiliations of Thomas Simmet include University of Freiburg & French Institute of Health and Medical Research.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

Amna Abderrazak, +8 more
- 01 Apr 2015 - 
TL;DR: This review has updated knowledge on NLRP3 inflammasome assembly and activation and on the pyrin domain inNLRP3 that could represent a drug target to treat sterile inflammatory diseases, and reported mutations in NL RP3 that were found to be associated with certain diseases.
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Differential Uptake of Functionalized Polystyrene Nanoparticles by Human Macrophages and a Monocytic Cell Line

Oleg Lunov, +11 more
- 23 Feb 2011 - 
TL;DR: The data show that the amount of internalized nanoparticles, the uptake kinetics, and its mechanism may differ considerably between primary cells and a related tumor cell line, whether differentiated or not, and that particle uptake by these cells is critically dependent on particle opsonization by serum proteins.
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Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells

Stefanie Lindner, +16 more
- 15 Apr 2013 - 
TL;DR: These findings establish the existence of human B cells with a regulatory phenotype in solid tumor infiltrates, where they may contribute to the suppression of antitumor immune responses and stimulate novel diagnostic and cell therapeutic approaches to better manage human cancer as well as autoimmune and graft-versus-host pathologies.
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The thioredoxin system as a therapeutic target in human health and disease

Dler Faieeq Darweesh Mahmood, +4 more
- 26 Sep 2013 - 
TL;DR: The biological properties of the Trx system are highlighted, and its implications in several human diseases are discussed, including cardiovascular diseases, heart failure, stroke, inflammation, metabolic syndrome, neurodegenerative diseases, arthritis, and cancer.