Autophagy and Tumor Metabolism

doi:10.1016/J.CMET.2017.04.004

Open AccessJournal ArticleDOI

Autophagy and Tumor Metabolism

Alec C. Kimmelman, +1 more

- 02 May 2017 -

Cell Metabolism

- Vol. 25, Iss: 5, pp 1037-1043

TLDR

The diverse metabolic fuel sources that can be produced by autophagy provide tumors with metabolic plasticity and can allow them to thrive in what can be an austere microenvironment, and understanding how autophile can fuel cellular metabolism will enable more effective combinatorial therapeutic strategies.

About:

This article is published in Cell Metabolism.The article was published on 2017-05-02 and is currently open access. It has received 565 citations till now. The article focuses on the topics: Autophagy.

Citations

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Mechanism and medical implications of mammalian autophagy

Ivan Dikic, +1 more

- 01 Jun 2018 -

Nature Reviews Molecular Cell Biology

TL;DR: It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.

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Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine, +1 more

- 10 Jan 2019 -

Cell

TL;DR: The biological functions of autophagy genes are discussed from the perspective of understanding-and potentially reversing-the pathophysiology of human disease and aging.

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Journal ArticleDOI

Nrf2-Keap1 signaling in oxidative and reductive stress.

Ilaria Bellezza, +3 more

- 01 May 2018 -

Biochimica et Biophysica Acta

TL;DR: The effects of the Nrf2-Keap1 system in the physiology and pathophysiology of striated muscle tissue taking into account its role(s) in oxidative stress and reductive stress are highlighted.

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Journal ArticleDOI

NRF2 and the Hallmarks of Cancer.

Montserrat Rojo de la Vega, +2 more

- 09 Jul 2018 -

Cancer Cell

TL;DR: The roles of NRF2 in the hallmarks of cancer are explored, indicating both tumor suppressive and tumor-promoting effects.

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Journal ArticleDOI

Targeting autophagy in cancer

Angelique Onorati, +3 more

- 15 Aug 2018 -

Cancer

TL;DR: Fundamental advances in the biology of autophagy are presented, approaches to targeting Autophagy, the preclinical rationale and clinical experience with hydroxychloroquine in cancer clinical trials, the potential role ofAutophagy in tumor immunity, and recent developments in next‐generation autophagic inhibitors that have clinical potential are presented.

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References

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