Yingjie Sun

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The structure shows that Leu166 positions in the middle of a helix and thus predicts that the L166P mutation will bend theHelix and impact the dimerization of DJ‐1, leading to the familial Parkinson's disease caused by the single L166p mutation.

TL;DR: The crystal structures of the PDE4D2 catalytic domain in complex with (R)- or (R,S)-rolipram suggest that inhibitor selectivity is determined by the chemical nature of amino acids and subtle conformational changes of the binding pockets, and the corresponding Y329S mutation in PDE7 may lead to loss of the hydrogen bonds between rolipram and Gln369.