Autophagy in cancer: a complex relationship.

doi:10.1042/BCJ20170847

Journal ArticleDOI

Autophagy in cancer: a complex relationship.

Lindsay Wilde, +3 more

- 15 Jun 2018 -

Biochemical Journal

- Vol. 475, Iss: 11, pp 1939-1954

Chats0

TLDR

This review will explore the connections between autophagy and cancer, which are tumor- and context-dependent and include the tumor microenvironment, and highlight the importance of tumor compartment-specific autophagic in both cancer aggressiveness and treatment.

Abstract:

Macroautophagy is the process by which cells package and degrade cytosolic components, and recycle the breakdown products for future use. Since its initial description by Christian de Duve in the 1960s, significant progress has been made in understanding the mechanisms that underlie this vital cellular process and its specificity. Furthermore, macroautophagy is linked to pathologic conditions such as cancer and is being studied as a therapeutic target. In this review, we will explore the connections between autophagy and cancer, which are tumor- and context-dependent and include the tumor microenvironment. We will highlight the importance of tumor compartment-specific autophagy in both cancer aggressiveness and treatment.

Citations

PDF

Open Access

More filters

Journal ArticleDOI

Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway

Jin Zhou, +4 more

- 01 Feb 2020 -

Cell Proliferation

TL;DR: This study aimed to access the therapy effect of Tan‐Ⅰ and the underlying mechanisms by which Tan‐ Ⅰ regulates apoptosis and autophagy in ovarian cancer.

...read moreread less

Journal ArticleDOI

Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation.

Haitao Pan, +8 more

- 11 Jun 2019 -

Cell Death and Disease

TL;DR: It is demonstrated that GLP-induced autophagosome accumulation and apoptosis is mediated via MAPK/ERK activation, and GLP inhibited tumor growth and also inhibited autophagic flux in vivo.

...read moreread less

Journal ArticleDOI

Starvation-induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF-β1/Smad3-mediated epithelial-mesenchymal transition activation.

Hang Tong, +8 more

- 01 Apr 2019 -

Journal of Cellular Biochemistry

TL;DR: It is suggested that autophagy promotes the invasion and migration of bladder cancer cells by inducing EMT through the TGF‐β1/Smad3 signaling pathway and can form a positive feedback loop to synergistically promote invasion and Migration.

...read moreread less

Journal ArticleDOI

p62-mediated Selective Autophagy Endows Virus-Transformed Cells With Insusceptibility to DNA Damage Under Oxidative Stress

Ling Wang, +11 more

- 24 Apr 2019 -

PLOS Pathogens

TL;DR: Evidence is provided that considerable levels of p62-mediated selective autophagy are spontaneously induced, and correlate with ROS-Keap1-NRF2 pathway activity, in virus-transformed cells, and a novel insight into virus-mediated oncogenesis is provided.

...read moreread less

Journal ArticleDOI

Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer.

Yasuyoshi Miyata, +6 more

- 10 Aug 2018 -

Medicines

TL;DR: The potential usefulness of green Tea as an antibladder cancer agent and the future direction of green tea-based treatment strategies for patients with bladder cancer are discussed.

...read moreread less

Collapse

References

PDF

Open Access

More filters

Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more

- 01 Feb 2011 -

Nature Cell Biology

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

...read moreread less

Journal ArticleDOI

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

Sophie Pattingre, +11 more

- 23 Sep 2005 -

Cell

TL;DR: Bcl-2 not only functions as an antiapoptotic protein, but also as an antiautophagy protein via its inhibitory interaction with Beclin 1, which may help maintain autophagy at levels that are compatible with cell survival, rather than cell death.

...read moreread less

Journal ArticleDOI

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Dana M. Gwinn, +7 more

- 25 Apr 2008 -

Molecular Cell

TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.

...read moreread less

Journal ArticleDOI

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri, +5 more

- 01 Sep 2007 -

Nature Reviews Molecular Cell Biology

TL;DR: The functional relationship between apoptosis and autophagy is complex in the sense that, under certain circumstances,autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway.

...read moreread less

Journal ArticleDOI

Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Xiao Huan Liang, +6 more

- 09 Dec 1999 -

Nature

TL;DR: It is shown that beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma, suggesting that decreased expression of Autophagy proteins may contribute to the development or progression of breast and other human malignancies.

...read moreread less