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Chang-Shen Lin

Researcher at Kaohsiung Medical University

Publications -  68
Citations -  6760

Chang-Shen Lin is an academic researcher from Kaohsiung Medical University. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 22, co-authored 60 publications receiving 6079 citations. Previous affiliations of Chang-Shen Lin include Tri-Service General Hospital & National Sun Yat-sen University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Biotransformation of cyanide to methane and ammonia by Klebsiella oxytoca.

TL;DR: Results from this study show that the processes of cyanide biodegradation and ammonia production by resting cells occurred simultaneously, which suggests that the utilization of cyanides as nitrogen source by K. oxytoca might proceed using ammonia as an assimilatory substrate.
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Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells

TL;DR: It is shown that arecoline, a major alkaloid of areca nut, might contribute to oral carcinogenesis through inhibiting p53 and DNA repair and that p53 mRNA transcripts were frequently down-regulated in BQ-associated oral cancer, suggesting that are coline-mediated p53 inhibition might play a role in Bq-associated tumorigenesis.
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Epstein-Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells.

TL;DR: It is suggested that disruption of DNA repair by LMP-1 results in an accumulation of unrepaired DNA and consequent genomic instability, which may contribute to the oncogenesis of LMP1 in human epithelial cells.
Journal Article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2459 more
- 01 Jan 2016 -