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Open AccessJournal ArticleDOI

Atg8‐family interacting motif crucial for selective autophagy

Nobuo N. Noda, +2 more
- 02 Apr 2010 - 
- Vol. 584, Iss: 7, pp 1379-1385
TLDR
Structural studies have uncovered the conserved specific interactions between autophagic receptors and Atg8‐family proteins through WXXL‐like sequences, which are termed the Atg 8‐family interacting motif (AIM) and may link the target–receptor complex to Autophagic membranes and/or their forming machineries.
About: 
This article is published in FEBS Letters.The article was published on 2010-04-02 and is currently open access. It has received 472 citations till now. The article focuses on the topics: Autophagy-Related Protein 8 Family & ATG8.

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Citations
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Mechanisms of mitophagy

Richard J. Youle, +2 more
- 01 Jan 2011 - 
TL;DR: Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, and in mammals during red blood cell differentiation, mediated by NIP3-like protein X (NIX; also known as BNIP3L).
Journal ArticleDOI

The Role of Atg Proteins in Autophagosome Formation

Noboru Mizushima, +2 more
- 10 Oct 2011 - 
TL;DR: The molecular mechanism of autophagosome formation is described with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagous membrane membrane.
Journal ArticleDOI

Selective autophagy mediated by autophagic adapter proteins

Terje Johansen, +1 more
- 01 Mar 2011 - 
TL;DR: The mechanistic basis of selective autophagy in mammalian cells discussing the degradation of misfolded proteins, p62 bodies, aggresomes, mitochondria and invading bacteria is reviewed and the emerging picture of selectivity affecting the regulation of cell signaling with consequences for oxidative stress responses, tumorigenesis and innate immunity is addressed.
Journal ArticleDOI

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

Lei Liu, +21 more
- 22 Jan 2012 - 
TL;DR: It is reported that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy, and its findings offer insights into mitochondrial quality control in mammalian cells.
References
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Journal ArticleDOI

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Yukiko Kabeya, +13 more
- 01 Nov 2000 - 
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more
- 28 Feb 2008 - 
TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
Journal ArticleDOI

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, +12 more
- 15 Jun 2006 - 
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, +8 more
- 17 Aug 2007 - 
TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.
Journal ArticleDOI

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, +12 more
- 15 Jun 2006 - 
TL;DR: It is found that mice lacking Atg7 specifically in the central nervous system showed behavioural defects, including abnormal limb-clasping reflexes and a reduction in coordinated movement, and died within 28 weeks of birth, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies.
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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Selective autophagy mediated by autophagic adapter proteins

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