Autophagy and Ferroptosis—What Is the Connection?

doi:10.1007/S40139-017-0139-5

Open AccessJournal ArticleDOI

Autophagy and Ferroptosis—What Is the Connection?

Rui Kang, +1 more

- 20 Apr 2017 -

Current Pathobiology Reports

- Vol. 5, Iss: 2, pp 153-159

TLDR

This review highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.

Abstract:

Purpose of Review Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level.

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The molecular machinery of regulated cell death

Daolin Tang, +5 more

- 04 Apr 2019 -

Cell Research

TL;DR: The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.

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Journal ArticleDOI

Ferroptosis: machinery and regulation

Xin Chen, +6 more

- 02 Sep 2021 -

Autophagy

TL;DR: The recent rapid progress in understanding the molecular mechanisms of ferroptosis is reviewed and the epigenetic, transcriptional, and posttranslational regulation of this process is focused on.

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Journal ArticleDOI

Ferroptosis is a type of autophagy-dependent cell death.

Borong Zhou, +5 more

- 01 Nov 2020 -

Seminars in Cancer Biology

TL;DR: Current knowledge on the signaling pathways involved in ferroptosis is summarized, while focusing on the regulation of autophagy-dependent ferroptic cell death, which may lead to the development of novel anticancer therapies.

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Journal ArticleDOI

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation.

Eunhee Park, +1 more

- 28 Oct 2019 -

Cell Death and Disease

TL;DR: Autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/− and LC3B−/−.

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Journal ArticleDOI

Autophagy-Dependent Ferroptosis: Machinery and Regulation

Jiao Liu, +6 more

- 16 Apr 2020 -

Chemistry & Biology

TL;DR: In this article, the role of autophagy, especially selective types, in driving cells toward ferroptotic death was explored and the functional interactions between metabolism, immunity, and cell death were explored.

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References

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Cell

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Cell

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