Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

doi:10.1016/J.YJMCC.2019.09.001

Open AccessJournal ArticleDOI

Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

Yan Dong, +5 more

- 01 Nov 2019 -

Journal of Molecular and Cellular Cardio...

- Vol. 136, pp 27-41

TLDR

Treatment concept for CHD is provided by balancing the switch between the two responses of apoptosis and autophagy and some therapeutic drugs and pharmacologic compounds involving mTOR inhibitor and AMPK activator have been reported to regulate apoptosis.

About:

This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2019-11-01 and is currently open access. It has received 205 citations till now. The article focuses on the topics: Autophagy & Coronary atherosclerosis.

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The regulatory roles of p53 in cardiovascular health and disease.

Hongbo Men, +11 more

- 01 Mar 2021 -

Cellular and Molecular Life Sciences

TL;DR: The different effects of p53 in cardiovascular physiological and pathological conditions are described, in addition to potential CVD therapies targeting p53.

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Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis.

Mengtao Han, +5 more

- 15 Jan 2022 -

Gene

TL;DR: In this paper, the authors investigated the effect of Resveratrol (Res) on myocardial I/R injury and explored its potential mechanism, including reducing oxidative stress and attenuating ferroptosis.

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Journal ArticleDOI

Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis

Mengtao Han

- 01 Jan 2022 -

Gene

TL;DR: In this article , the authors investigated the effect of Resveratrol on myocardial I/R injury and explored its potential mechanism, and found that Res inhibited ferroptosis by the regulation of ubiquity specific peptidase 19 (USP19)-Beclin1 autophagy.

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Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miRNA-29c Decreases Cardiac Ischemia/Reperfusion Injury Through Inhibition of Excessive Autophagy via the PTEN/Akt/mTOR Signaling Pathway

Te Li, +5 more

- 22 Jul 2020 -

Circulation

TL;DR: The role of miR-29c in regulating autophagy under cardiac I/R injury is highlighted, which also extended existing mechanisms of a stem cell and its derivative to explore potential therapeutic interventions in ischemic heart diseases.

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Journal ArticleDOI

Resolvin E1 protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress, autophagy and apoptosis by targeting AKT/mTOR signaling

Jishou Zhang, +10 more

- 01 Aug 2020 -

Biochemical Pharmacology

TL;DR: Investigation of whether RvE1 protects against DOX-induced cardiotoxicity via the regulation of AKT/mTOR signaling found that it did, and the underlying mechanism was explored.

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References

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Apoptosis: A Review of Programmed Cell Death

Susan A. Elmore

- 01 Jun 2007 -

Toxicologic Pathology

TL;DR: The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptoses in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptotic proteins.

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Inflammation, Atherosclerosis, and Coronary Artery Disease

Göran K. Hansson

- 21 Apr 2005 -

The New England Journal of Medicine

TL;DR: The evidence is recounted that atherosclerosis, the main cause of CAD, is an inflammatory disease in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial tree.

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Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more

- 28 Feb 2008 -

Nature

TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.

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TOR signaling in growth and metabolism.

Stephan Wullschleger, +2 more

- 10 Feb 2006 -

Cell

TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.

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Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more

- 01 Feb 2011 -

Nature Cell Biology

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

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