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Open AccessJournal ArticleDOI

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer

Ilya Gukovsky, +6 more
- 01 May 2013 - 
- Vol. 144, Iss: 6, pp 1199-1209
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TLDR
The roles of inflammation and autophagy, and their deregulation by obesity, in pancreatic diseases are reviewed and the connections among disordered pathways and important areas for future research are discussed.
About: 
This article is published in Gastroenterology.The article was published on 2013-05-01 and is currently open access. It has received 282 citations till now. The article focuses on the topics: Pancreatitis & Autophagy.

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American association of clinical endocrinologists and american college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity.

W. Timothy Garvey, +8 more
- 03 Aug 2016 - 
TL;DR: The final recommendations recognize that obesity is a complex, adiposity-based chronic disease, where management targets both weight-related complications and adiposity to improve overall health and quality of life.
Journal ArticleDOI

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

Matthew Spite, +2 more
- 07 Jan 2014 - 
TL;DR: Evidence is reviewed that the failure of resolution programs contributes to metabolic diseases and that SPMs may play pivotal roles in their resolution, and specialized proresolving lipid mediators (SPMs) are novel autacoids that resolve inflammation, protect organs, and stimulate tissue regeneration.
Journal ArticleDOI

Pancreatic cancer biology and genetics from an evolutionary perspective

Alvin Makohon-Moore, +1 more
- 01 Sep 2016 - 
TL;DR: The wide-ranging aspects of pancreatic cancer research are gathered into a single concept rooted in Darwinian evolution, with the goal of identifying novel insights and opportunities for study.
Book ChapterDOI

Reactive oxygen species in normal and tumor stem cells.

Daohong Zhou, +2 more
- 01 Jan 2014 - 
TL;DR: This chapter discusses how the production of ROS in normal stem cells is regulated by various intrinsic and extrinsic factors and how the fate of these cells is altered by the dysregulation of ROS production under various pathological conditions.
Journal ArticleDOI

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

Roland Lang, +6 more
- 01 Jan 2015 - 
TL;DR: In this review, the importance of novel galanin receptor–specific agonists and antagonists are emphasized, and new approaches, including new transgenic mouse lines (such as a recently characterized GAL3 knockout mouse) represent, in combination with viral-based techniques, critical tools required to better evaluate Galanin system physiology.
References
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Journal ArticleDOI

Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, +5 more
- 15 Dec 2003 - 
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
Journal ArticleDOI

Immunity, Inflammation, and Cancer

Sergei I. Grivennikov, +2 more
- 19 Mar 2010 - 
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Book

Pancreatic Cancer

Preston Spencer, +2 more
Journal ArticleDOI

Autophagy in the Pathogenesis of Disease

Beth Levine, +3 more
- 11 Jan 2008 - 
TL;DR: This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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