hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.
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The data suggest that hVps34 is a nutrient-regulated lipid kinase that integrates amino acid and glucose inputs to mTOR and S6K1 and is a critical component of the nutrient sensing apparatus.About:
This article is published in Journal of Biological Chemistry.The article was published on 2005-09-23 and is currently open access. It has received 542 citations till now. The article focuses on the topics: P70-S6 Kinase 1 & mTORC2.read more
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TOR signaling in growth and metabolism.
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
Journal ArticleDOI
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Kumar,Anuj Kumar,Ashok Kumar,Deepak Kumar,Dhiraj Kumar,Rakesh Kumar,Sharad Kumar,Mondira Kundu,Hsing Jien Kung,Hsing Jien Kung,Atsushi Kuno,Sheng-Han Kuo,Jeff Kuret,Tino Kurz,Terry Kwok,Taeg Kyu Kwon,Yong Tae Kwon,Irene Kyrmizi,Albert R. La Spada,Frank Lafont,Tim Lahm,Aparna Lakkaraju,Truong Lam,Trond Lamark,Steve Lancel,Terry H. Landowski,Darius J.R. Lane,Jon D. Lane,Cinzia Lanzi,Pierre Lapaquette,Louis R. Lapierre,Jocelyn Laporte,Johanna Laukkarinen,Gordon W. Laurie,Sergio Lavandero,Sergio Lavandero,Lena Lavie,Matthew J. LaVoie,Betty Yuen Kwan Law,Helen K. W. Law,Kelsey B. Law,Robert Layfield,Pedro A. Lazo,Laurent Le Cam,Karine G. Le Roch,Hervé Le Stunff,Hervé Le Stunff,Vijittra Leardkamolkarn,Marc Lecuit,Byung-Hoon Lee,Che Hsin Lee,Erinna F. Lee,Gyun Min Lee,He Jin Lee,Hsinyu Lee,Jae Keun Lee,Jongdae Lee,Ju-Hyun Lee,Ju-Hyun Lee,Jun Hee Lee,Michael Lee,Myung-Shik Lee,Patty J. Lee,Sam W. Lee,Seung-Jae Lee,Shiow Ju Lee,Stella Y. Lee,Sug Hyung Lee,Sung Sik Lee,Sung Joon Lee,Sunhee Lee,Ying-Ray Lee,Yong J. Lee,Young H. Lee,Christiaan Leeuwenburgh,Sylvain Lefort,Renaud Legouis,Jinzhi Lei,Qun-Ying Lei,David A. Leib,Gil Leibowitz,Istvan Lekli,Stéphane D. Lemaire,John J. Lemasters,Marius K. Lemberg,Antoinette Lemoine,Shuilong Leng,Guido Lenz,Paola Lenzi,Lilach O. Lerman,Daniele Lettieri Barbato,Julia I-Ju Leu,Hing Y. Leung,Beth Levine,Beth Levine,Patrick A. Lewis,Patrick A. Lewis,Frank Lezoualc'h,Chi Li,Faqiang Li,Feng Jun Li,Jun Li,Ke Li,Lian Li,Min Li,Min Li,Qiang Li,Rui Li,Sheng Li,Wei Li,Wei Li,Xiaotao Li,Yumin Li,Jiqin Lian,Chengyu Liang,Qiangrong Liang,Yulin Liao,Joana Liberal,Pawel P. Liberski,Pearl P.Y. Lie,Andrew P. Lieberman,Hyunjung Jade Lim,Kah-Leong Lim,Kyu Lim,Raquel T. Lima,Chang-Shen Lin,Chang-Shen Lin,Chiou Feng Lin,Fang Lin,Fangming Lin,Fu-Cheng Lin,Kui Lin,Kwang-Huei Lin,Pei-Hui Lin,Tianwei Lin,Wan-Wan Lin,Yee Shin Lin,Yong Lin,Rafael Linden,Dan Lindholm,Lisa M Lindqvist,Paul Lingor,Andreas Linkermann,Lance A. Liotta,Marta M. Lipinski,Vitor A. Lira,Michael P. Lisanti,Paloma B. Liton,Bo Liu,Chong Liu,Chun-Feng Liu,Fei Liu,Hung-Jen Liu,Jian-Xun Liu,Jingjing Liu,Jing Lan Liu,Ke Liu,Leyuan Liu,Liang Liu,Quentin Liu,Rong Yu Liu,Shiming Liu,Shuwen Liu,Wei Liu,Xian De Liu,Xiangguo Liu,Xiao Hong Liu,Xinfeng Liu,Xu Liu,Xueqin Liu,Yang Liu,Yule Liu,Zexian Liu,Zhe Liu,Juan P. Liuzzi,Gérard Lizard,Mila Ljujic,Irfan J. Lodhi,Susan E. Logue,Balakrishna L. Lokeshwar,Yun Chau Long,Sagar Lonial,Benjamin Loos,Carlos López-Otín,Cristina López-Vicario,Mar Lorente,Philip L. Lorenzi,Péter Lõrincz,Marek Los,Michael T. Lotze,Penny E. Lovat,Binfeng Lu,Bo Lu,Jia-Hong Lu,Qing Lu,She Min Lu,Shuyan Lu,Yingying Lu,Frederic Luciano,Shirley Luckhart,John M. Lucocq,Paula Ludovico,Aurelia Lugea,Nicholas W. Lukacs,Julian J. Lum,Anders H. Lund,Honglin Luo,Jia Luo,Shouqing Luo,Claudio Luparello,Timothy J. Lyons,Jianjie Ma,Yi Ma,Yong Ma,Zhenyi Ma,Juliano Machado,Gláucia Maria Machado-Santelli,Fernando Macian,Gustavo C. MacIntosh,Jeffrey P. MacKeigan,Kay F. Macleod,John D. MacMicking,Lee Ann MacMillan-Crow,Frank Madeo,Muniswamy Madesh,Julio Madrigal-Matute,Akiko Maeda,Tatsuya Maeda,Gustavo Maegawa,Emilia Maellaro,Hannelore Maes,Marta Magariños,Kenneth Maiese,Tapas K. Maiti,Luigi Maiuri,Maria Chiara Maiuri,Carl G. Maki,Roland Malli,Walter Malorni,Alina Maloyan,Fathia Mami-Chouaib,Na Man,Na Man,Joseph D. Mancias,Eva Maria Mandelkow,Michael A. Mandell,Angelo A. Manfredi,Serge N. Manié,Claudia Manzoni,Claudia Manzoni,Kai Mao,Zixu Mao,Zong Wan Mao,Philippe Marambaud,Anna Maria Marconi,Zvonimir Marelja,Gabriella Marfe,Marta Margeta,Éva Margittai,Muriel Mari,Francesca V. Mariani,Concepcio Marin,Sara Marinelli,Guillermo Mariño,Ivanka Markovic,Rebecca T. Marquez,Alberto M. Martelli,Sascha Martens,Katie R. Martin,Seamus J. Martin,Shaun Martin,Miguel A. Martín-Acebes,Paloma Martín-Sanz,Camille Martinand-Mari,Wim Martinet,Jennifer Martinez,Nuria Martinez-Lopez,Ubaldo E. Martinez-Outschoorn,Moisés Martínez-Velázquez,Marta Martinez-Vicente,Waleska Kerllen Martins,Hirosato Mashima,James A. Mastrianni,Giuseppe Matarese,Paola Matarrese,Roberto Mateo,Satoaki Matoba,Naomichi Matsumoto,Takehiko Matsushita,Akira Matsuura,Takeshi Matsuzawa,Mark P. Mattson,Soledad Matus,Norma Maugeri,Caroline Mauvezin,Andreas Mayer,Dusica Maysinger,Guillermo Mazzolini,Mary Kate McBrayer,Kimberly McCall,Craig McCormick,Gerald M. McInerney,Skye C. McIver,Sharon L. McKenna,John J. McMahon,Iain A. McNeish,Fatima Mechta-Grigoriou,Jan Paul Medema,Diego L. Medina,Klára Megyeri,Maryam Mehrpour,Jawahar L. Mehta,Yide Mei,Ute C. Meier,Alfred J. Meijer,Alicia Meléndez,Gerry Melino,Sonia Melino,Edésio José Tenório de Melo,Maria Angeles Mena,Marc D. Meneghini,Javier A. Menendez,Regina Menezes,Liesu Meng,Linghua Meng,Songshu Meng,Rossella Menghini,A. Sue Menko,Rubem F. S. Menna-Barreto,Manoj B. Menon,Marco Antonio Meraz-Ríos,Giuseppe Merla,Luciano Merlini,Angelica M. Merlot,Andreas Meryk,Stefania Meschini,Joel N. Meyer,Man Tian Mi,Chao-Yu Miao,Lucia Micale,Simon Michaeli,Carine Michiels,Anna Rita Migliaccio,Anastasia S. Mihailidou,Anastasia S. Mihailidou,Dalibor Mijaljica,Katsuhiko Mikoshiba,Enrico Milan,Leonor Miller-Fleming,Gordon B. Mills,Ian G. Mills,Ian G. Mills,Georgia Minakaki,Berge A. Minassian,Xiu-Fen Ming,Farida V. Minibayeva,Elena A. Minina,Justine D. Mintern,Saverio Minucci,Antonio Miranda-Vizuete,Claire H. Mitchell,Shigeki Miyamoto,Keisuke Miyazawa,Noboru Mizushima,Katarzyna Mnich,Baharia Mograbi,Simin Mohseni,Luis F. Moita,Marco Molinari,Maurizio Molinari,Maurizio Molinari,Andreas Buch Møller,Bertrand Mollereau,Faustino Mollinedo,Marco Mongillo,Martha M. Monick,Serena Montagnaro,Craig Montell,Darren J. Moore,Michael Moore,Rodrigo Mora-Rodriguez,Paula I. Moreira,Etienne Morel,Maria Beatrice Morelli,Sandra Moreno,Michael J. Morgan,Arnaud Moris,Yuji Moriyasu,Janna L. Morrison,Lynda A. Morrison,Eugenia Morselli,Jorge Moscat,Pope L. Moseley,Serge Mostowy,Elisa Motori,Denis Mottet,Jeremy C. Mottram,Charbel Moussa,Vassiliki E. Mpakou,Hasan Mukhtar,Jean M. Mulcahy Levy,Sylviane Muller,Raquel Muñoz-Moreno,Cristina Muñoz-Pinedo,Christian Münz,Maureen E. Murphy,James Murray,Aditya Murthy,Indira U. Mysorekar,Ivan R. Nabi,Massimo Nabissi,Gustavo A. Nader,Yukitoshi Nagahara,Yoshitaka Nagai,Kazuhiro Nagata,Anika Nagelkerke,Péter Nagy,Samisubbu R. Naidu,Sreejayan Nair,Hiroyasu Nakano,Hitoshi Nakatogawa,Meera Nanjundan,Gennaro Napolitano,Naweed I. Naqvi,Roberta Nardacci,Derek P. Narendra,Masashi Narita,Anna Chiara Nascimbeni,Ramesh Natarajan,Luiz Carlos Carvalho Navegantes,Steffan T. Nawrocki,Taras Y. Nazarko,Volodymyr Y. Nazarko,Thomas Neill,Luca M. Neri,Mihai G. Netea,Romana T. Netea-Maier,Bruno Miguel Neves,Paul A. Ney,Ioannis P. Nezis,Hang T.T. Nguyen,Huu Phuc Nguyen,Anne Sophie Nicot,Hilde Nilsen,Per Nilsson,Mikio Nishimura,Ichizo Nishino,Mireia Niso-Santano,Hua Niu,Ralph A. Nixon,Vincent C. O. Njar,Takeshi Noda,Angelika A. Noegel,E.M. Nolte,Erik Norberg,Koenraad Norga,Sakineh Kazemi Noureini,Shoji Notomi,Lucia Notterpek,Karin Nowikovsky,Nobuyuki Nukina,Thorsten Nürnberger,Valerie B. O'Donnell,Tracey R. O’Donovan,Peter J. O'Dwyer,Ina Oehme,Clara L. Oeste,Michinaga Ogawa,Besim Ogretmen,Yuji Ogura,Young J. Oh,Masaki Ohmuraya,Takayuki Ohshima,Rani Ojha,Koji Okamoto,Toshiro Okazaki,F. Javier Oliver,Karin Öllinger,Stefan Olsson,Daniel P. Orban,Paulina Ordonez,Idil Orhon,László Orosz,Eyleen J. O’Rourke,Helena Orozco,Angel Ortega,Elena Ortona,Laura D. Osellame,Junko Oshima,Shigeru Oshima,Heinz D. Osiewacz,Takanobu Otomo,Kinya Otsu,Jing Hsiung James Ou,Tiago F. Outeiro,Dong-Yun Ouyang,Hongjiao Ouyang,Michael Overholtzer,Michelle A. Ozbun,P. Hande Özdinler,Bulent Ozpolat,Consiglia Pacelli,Paolo Paganetti,Guylène Page,Gilles Pagès,Ugo Pagnini,Beata Pajak,Beata Pajak,Stephen C. Pak,Karolina Pakos-Zebrucka,Nazzy Pakpour,Zdena Palková,Francesca Palladino,Kathrin Pallauf,Nicolas Pallet,Marta Palmieri,Søren R. Paludan,Camilla Palumbo,Silvia Palumbo,Olatz Pampliega,Hongming Pan,Wei Pan,Theocharis Panaretakis,Aseem Pandey,Areti Pantazopoulou,Zuzana Papackova,Daniela L. Papademetrio,Issidora S. Papassideri,Alessio Papini,Nirmala Parajuli,Julián Pardo,Vrajesh V. Parekh,Giancarlo Parenti,Jong-In Park,Junsoo Park,Ohkmae K. Park,Roy Parker,Rosanna Parlato,Rosanna Parlato,Jan B. Parys,Katherine R. Parzych,Jean Max Pasquet,Benoit Pasquier,Kishore B.S. Pasumarthi,Cam Patterson,Cam Patterson,Sophie Pattingre,Scott Pattison,Arnim Pause,Hermann Pavenstädt,Flaminia Pavone,Zully Pedrozo,Fernando J. Peña,Miguel A. Peñalva,Mario Pende,Jianxin Peng,Fabio Penna,Josef M. Penninger,Anna Pensalfini,Salvatore Pepe,Gustavo J.S. Pereira,Paulo Pereira,Verónica Pérez de la Cruz,María Esther Pérez-Pérez,Diego Pérez-Rodríguez,Dolores Pérez-Sala,Celine Perier,Andras Perl,David H. Perlmutter,Ida Perrotta,Shazib Pervaiz,Shazib Pervaiz,Maija Pesonen,Jeffrey E. Pessin,Godefridus J. Peters,Morten Petersen,Irina Petrache,Basil J. Petrof,Goran Petrovski,Goran Petrovski,James M. Phang,Mauro Piacentini,Marina Pierdominici,Philippe Pierre,Valérie Pierrefite-Carle,Federico Pietrocola,Felipe X. Pimentel-Muiños,Mario Pinar,Benjamin Pineda,Ronit Pinkas-Kramarski,Marcello Pinti,Paolo Pinton,Bilal Piperdi,James M. Piret,Leonidas C. Platanias,Leonidas C. Platanias,Harald W. Platta,Edward D. Plowey,Stefanie Pöggeler,Marc Poirot,Peter Polčic,Angelo Poletti,Audrey H. Poon,Hana Popelka,Blagovesta Popova,Izabela Poprawa,Shibu M. Poulose,Joanna Poulton,Scott K. Powers,Ted Powers,Mercedes Pozuelo-Rubio,Krisna Prak,Reinhild Prange,Mark Prescott,Muriel Priault,Sharon Prince,Richard L. Proia,Tassula Proikas-Cezanne,Holger Prokisch,Vasilis J. Promponas,Karin Przyklenk,Rosa Puertollano,Subbiah Pugazhenthi,Luigi Puglielli,Aurora Pujol,Julien Puyal,Dohun Pyeon,Xin Qi,Wen Bin Qian,Zheng-Hong Qin,Yu Qiu,Ziwei Qu,Joe Quadrilatero,Frederick D. Quinn,Nina Raben,Hannah Rabinowich,Flavia Radogna,Michael J. Ragusa,Mohamed Rahmani,Komal Raina,Sasanka Ramanadham,Rajagopal Ramesh,Abdelhaq Rami,Sarron Randall-Demllo,Felix Randow,Felix Randow,Hai Rao,V. Ashutosh Rao,Blake B. Rasmussen,Tobias M. Rasse,Edward A. Ratovitski,Pierre-Emmanuel Rautou,Swapan K. Ray,Babak Razani,Bruce H. Reed,Fulvio Reggiori,Markus Rehm,Andreas S. Reichert,Theo Rein,David J. Reiner,Eric Reits,Jun Ren,Xingcong Ren,Maurizio Renna,Jane E.B. Reusch,Jane E.B. Reusch,José L. Revuelta,Leticia Reyes,Alireza R. Rezaie,Robert I. Richards,Des R. Richardson,Clémence Richetta,Michael A. Riehle,Bertrand H. Rihn,Yasuko Rikihisa,Brigit E. Riley,Gerald Rimbach,Maria Rita Rippo,Konstantinos Ritis,Federica Rizzi,Elizete Rizzo,Peter J. Roach,Jeffrey Robbins,Michel Roberge,Gabriela Roca,Maria Carmela Roccheri,Sonia Rocha,Cecília M. P. Rodrigues,Clara I. Rodríguez,Santiago Rodríguez de Córdoba,Natalia Rodriguez-Muela,Jeroen Roelofs,Vladimir V. Rogov,Troy T. Rohn,Bärbel Rohrer,Davide Romanelli,Luigina Romani,Patricia Silvia Romano,M. Isabel G. Roncero,Jose Luis Rosa,Alicia Rosello,Kirill V. Rosen,Philip Rosenstiel,Magdalena Rost-Roszkowska,Kevin A. Roth,Gaël Roué,Mustapha Rouis,Kasper M.A. Rouschop,Daniel T. Ruan,Diego Ruano,David C. Rubinsztein,Edmund B. Rucker,Assaf Rudich,Emil Rudolf,Ruediger Rudolf,Markus A. Rüegg,Carmen Ruiz-Roldán,Avnika A. Ruparelia,Paola Rusmini,David W. Russ,Gian Luigi Russo,Giuseppe Russo,Rossella Russo,Tor Erik Rusten,Victoria Ryabovol,Kevin M. Ryan,Stefan W. Ryter,David M. Sabatini,Michael Sacher,Michael Sacher,Carsten Sachse,Michael N. Sack,Junichi Sadoshima,Paul Saftig,Ronit Sagi-Eisenberg,Sumit Sahni,Pothana Saikumar,Tsunenori Saito,Tatsuya Saitoh,Koichi Sakakura,Machiko Sakoh-Nakatogawa,Yasuhito Sakuraba,María Salazar-Roa,Paolo Salomoni,Ashok K. Saluja,Paul M. Salvaterra,Rosa Salvioli,Afshin Samali,Anthony Sanchez,José Antonio Sánchez-Alcázar,Ricardo Sánchez-Prieto,Marco Sandri,Miguel A. Sanjuan,Stefano Santaguida,Laura Santambrogio,Giorgio Santoni,Cláudia N. Santos,Shweta Saran,Marco Sardiello,Graeme Sargent,Pallabi Sarkar,Sovan Sarkar,Maria Rosa Sarrias,Minnie M. Sarwal,Chihiro Sasakawa,Motoko Sasaki,Miklós Sass,Ken Sato,Miyuki Sato,Joseph Satriano,Niramol Savaraj,Svetlana Saveljeva,Liliana Schaefer,Ulrich E. Schaible,Michael Scharl,Hermann M. Schätzl,Randy Schekman,Wiep Scheper,Alfonso Schiavi,Hyman M. Schipper,Hana Schmeisser,Jens Schmidt,Ingo Schmitz,B. Schneider,E. Marion Schneider,Jaime L. Schneider,Eric A. Schon,Miriam J. Schönenberger,Axel H. Schönthal,Daniel F. Schorderet,Bernd Schröder,Sebastian Schuck,Ryan J. Schulze,Melanie Schwarten,Thomas Schwarz,Sebastiano Sciarretta,Sebastiano Sciarretta,Kathleen W. Scotto,A. Ivana Scovassi,Robert A. Screaton,Mark Screen,Hugo Seca,Simon Sedej,Laura Segatori,Nava Segev,Per Ottar Seglen,Jose M. Seguí-Simarro,Juan Segura-Aguilar,Iban Seiliez,Ekihiro Seki,Christian Sell,Clay F. Semenkovich,Gregg L. Semenza,Utpal Sen,Andreas L. Serra,Ana Serrano-Puebla,Hiromi Sesaki,Takao Setoguchi,Carmine Settembre,John J. Shacka,Ayesha N. Shajahan-Haq,Irving M. Shapiro,Shweta Sharma,Hua She,C. K.James Shen,Chiung Chyi Shen,Han-Ming Shen,Sanbing Shen,Weili Shen,Rui Sheng,Xianyong Sheng,Zu-Hang Sheng,Trevor G. Shepherd,Junyan Shi,Qiang Shi,Qinghua Shi,Yuguang Shi,Shusaku Shibutani,Kenichi Shibuya,Yoshihiro Shidoji,Jeng-Jer Shieh,Chwen Ming Shih,Yohta Shimada,Shigeomi Shimizu,Dong Wook Shin,Mari L. Shinohara,Michiko Shintani,Takahiro Shintani,Tetsuo Shioi,Ken Shirabe,Ronit Shiri-Sverdlov,Orian S. Shirihai,Gordon C. Shore,Chih-Wen Shu,Deepak Shukla,Andriy A. Sibirny,Andriy A. Sibirny,Valentina Sica,Christina J. Sigurdson,Einar M. Sigurdsson,Puran Singh Sijwali,Beata Sikorska,Wilian A. Silveira,Sandrine Silvente-Poirot,Gary A. Silverman,Jan Simak,Thomas Simmet,Anna Katharina Simon,Hans-Uwe Simon,Cristiano Simone,Matias Simons,Anne Simonsen,Rajat Singh,Shivendra V. Singh,Shrawan Kumar Singh,Debasish Sinha,Sangita C. Sinha,Frank A. Sinicrope,Agnieszka Sirko,Kapil Sirohi,Balindiwe J.N. Sishi,Annie Sittler,Parco M. Siu,Efthimios Sivridis,Anna Skwarska,Ruth S. Slack,Iva Slaninová,Nikolai Slavov,Soraya S. Smaili,Keiran S.M. Smalley,Duncan R. Smith,Stefaan J. Soenen,Scott A. Soleimanpour,Anita Solhaug,Kumaravel Somasundaram,Jin H. Son,Avinash Sonawane,Chunjuan Song,Fuyong Song,Hyun Kyu Song,Ju-Xian Song,Wei Song,Kai Y. Soo,Anil K. Sood,Tuck Wah Soong,Virawudh Soontornniyomkij,Maurizio Sorice,Federica Sotgia,David R. Soto-Pantoja,Areechun Sotthibundhu,Maria João Sousa,Herman P. Spaink,Paul N. Span,Anne Spang,Janet D. Sparks,Peter Speck,Stephen A. Spector,Claudia Spies,Wolfdieter Springer,Daret K. St. Clair,Alessandra Stacchiotti,Bart Staels,Michael T. Stang,Daniel T. Starczynowski,Petro Starokadomskyy,Clemens Steegborn,John W. Steele,Leonidas Stefanis,Joan S. Steffan,Christine M. Stellrecht,Harald Stenmark,Tomasz M. Stepkowski,Stephan T. Stern,Craig Stevens,Brent R. Stockwell,Veronika Stoka,Zuzana Storchova,Björn Stork,Vassilis Stratoulias,Dimitrios J. Stravopodis,Pavel Strnad,Anne M. Strohecker,Anna-Lena Ström,Per E. Stromhaug,Jiri Stulik,Yu Xiong Su,Zhaoliang Su,Carlos S. Subauste,Srinivasa Subramaniam,Carolyn M. Sue,Sang Won Suh,Xinbing Sui,Supawadee Sukseree,David Sulzer,Fang Lin Sun,Jiaren Sun,Jun Sun,Shi-Yong Sun,Yang Sun,Yi Sun,Yingjie Sun,Vinod Sundaramoorthy,Joseph J.Y. Sung,Hidekazu Suzuki,Kuninori Suzuki,Naoki Suzuki,Tadashi Suzuki,Yuichiro J. Suzuki,Michele S. Swanson,Charles Swanton,Karl Swärd,Ghanshyam Swarup,Sean T. Sweeney,Paul W. Sylvester,Zsuzsanna Szatmári,Eva Szegezdi,Peter W. Szlosarek,Heinrich Taegtmeyer,Marco Tafani,Emmanuel Taillebourg,Stephen W.G. Tait,Krisztina Takács-Vellai,Yoshinori Takahashi,Szabolcs Takáts,Genzou Takemura,Nagio Takigawa,Nicholas J. Talbot,Elena Tamagno,Jerome Tamburini,Cai Ping Tan,Lan Tan,Mei Lan Tan,Ming Tan,Yee-Joo Tan,Yee-Joo Tan,Keiji Tanaka,Masaki Tanaka,Daolin Tang,Dingzhong Tang,Guomei Tang,Isei Tanida,Kunikazu Tanji,Bakhos A. Tannous,Jose A. Tapia,Inmaculada Tasset-Cuevas,Marc Tatar,Iman Tavassoly,Nektarios Tavernarakis,Nektarios Tavernarakis,Allen Taylor,Graham S. Taylor,Gregory A. Taylor,J. Paul Taylor,Mark J. Taylor,Elena V. Tchetina,Andrew R. Tee,Fatima Teixeira-Clerc,Sucheta Telang,Tewin Tencomnao,Ba-Bie Teng,Ru Jeng Teng,Faraj Terro,Gianluca Tettamanti,Arianne L. Theiss,Anne Elisabeth Theron,Kelly Jean Thomas,Marcos P. Thomé,Paul G. Thomes,Andrew Thorburn,Jeremy Thorner,Thomas Thum,Michael Thumm,Teresa L. M. Thurston,Ling Tian,Andreas Till,Andreas Till,Jenny P.-Y. Ting,Vladimir I. Titorenko,Lilach Toker,Stefano Toldo,Sharon A. Tooze,Ivan Topisirovic,Maria Lyngaas Torgersen,Liliana Torosantucci,Alicia Torriglia,Maria Rosaria Torrisi,Cathy Tournier,Roberto Towns,Vladimir Trajkovic,Leonardo H. Travassos,Gemma Triola,Durga Nand Tripathi,Daniela Trisciuoglio,Rodrigo Troncoso,Ioannis P. Trougakos,Anita C. Truttmann,Kuen Jer Tsai,Mario P. Tschan,Yi Hsin Tseng,Takayuki Tsukuba,Allan Tsung,Andrey S. Tsvetkov,Shuiping Tu,Hsing Yu Tuan,Marco Tucci,David A. Tumbarello,Boris Turk,Vito Turk,Robin F. B. Turner,Anders Aune Tveita,Suresh C. Tyagi,Makoto Ubukata,Yasuo Uchiyama,Andrej Udelnow,Takashi Ueno,Midori Umekawa,Rika Umemiya-Shirafuji,Benjamin R. Underwood,Christian Ungermann,Rodrigo Portes Ureshino,Ryo Ushioda,Vladimir N. Uversky,Néstor L. Uzcátegui,Thomas Vaccari,Maria I. Vaccaro,Libuše Váchová,Helin Vakifahmetoglu-Norberg,Rut Valdor,Enza Maria Valente,François M. Vallette,Ángela M. Valverde,Greet Van den Berghe,Ludo Van Den Bosch,Gijs R. van den Brink,F. Gisou van der Goot,Ida J. van der Klei,Luc J. W. van der Laan,Wouter G. van Doorn,Marjolein van Egmond,Kenneth L. van Golen,Kenneth L. van Golen,Luc Van Kaer,Menno van Lookeren Campagne,Peter Vandenabeele,Wim Vandenberghe,Ilse Vanhorebeek,Isabel Varela-Nieto,M. Helena Vasconcelos,Radovan Vasko,Demetrios G. Vavvas,Ignacio Vega-Naredo,Guillermo Velasco,Athanassios D. Velentzas,Panagiotis D. Velentzas,Tibor Vellai,Edo Vellenga,Mikkel H. Vendelbo,Kartik Venkatachalam,Natascia Ventura,Salvador Ventura,Patrícia Sampaio Tavares Veras,Mireille Verdier,Beáta G. Vértessy,Andrea Viale,Michel Vidal,Helena L. A. Vieira,Richard D. Vierstra,Nadarajah Vigneswaran,Neeraj Vij,Miquel Vila,Margarita Villar,Victor H. Villar,Joan Villarroya,Cécile Vindis,Giampietro Viola,Maria Teresa Viscomi,Giovanni Vitale,Dan T. Vogl,Olga V. Voitsekhovskaja,Clarissa von Haefen,Karin von Schwarzenberg,Daniel E. Voth,Valérie Vouret-Craviari,Kristina Vuori,Jatin M. Vyas,Christian Waeber,Cheryl L. Walker,Mark J. Walker,Jochen Walter,Lei Wan,Lei Wan,Xiangbo Wan,Bo Wang,Caihong Wang,Chao-Yung Wang,Chengshu Wang,Chenran Wang,Chuangui Wang,Dong Wang,Fen Wang,Fuxin Wang,Guanghui Wang,Hai Jie Wang,Haichao Wang,Hong Gang Wang,Hongmin Wang,Horng-Dar Wang,Jing Wang,Junjun Wang,Mei Wang,Mei Qing Wang,Pei-Yu Wang,Peng Wang,Richard C. Wang,Shuo Wang,Ting-Fang Wang,Xian Wang,Xiao Jia Wang,Xiaowei Wang,Xin Wang,Xuejun Wang,Yan Wang,Yanming Wang,Ying Wang,Ying Jan Wang,Yipeng Wang,Yu Wang,Yu Tian Wang,Yuqing Wang,Zhi Nong Wang,Pablo Wappner,Carl Ward,Diane M. Ward,Gary Warnes,Hirotaka Watada,Yoshihisa Watanabe,Kei Watase,Timothy E. Weaver,Colin D. Weekes,Jiwu Wei,Thomas Weide,Conrad C. Weihl,Günther Weindl,Simone Nardin Weis,Longping Wen,Xin Wen,Yunfei Wen,Benedikt Westermann,Cornelia M. Weyand,Anthony R. White,Eileen White,J. Lindsay Whitton,Alexander J. Whitworth,Joëlle Wiels,Franziska Wild,Manon E. Wildenberg,Thomas Wileman,Deepti S. Wilkinson,Simon Wilkinson,Dieter Willbold,Chris Williams,Katherine Williams,Peter R. Williamson,Konstanze F. Winklhofer,Steven S. Witkin,Stephanie E. Wohlgemuth,Thomas Wollert,Ernst J. Wolvetang,Esther Wong,G. William Wong,Richard W. Wong,Vincent Kam Wai Wong,Elizabeth A. Woodcock,Karen L. Wright,Chunlai Wu,Defeng Wu,Gen Sheng Wu,Jian Wu,Junfang Wu,Mian Wu,Min Wu,Shengzhou Wu,William K.K. Wu,Yaohua Wu,Zhenlong Wu,Cristina P.R. Xavier,Ramnik J. 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Autophagy: process and function
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TL;DR: The current knowledge on the key genes composing the autophagy machinery in eukaryotes from yeast to mammalian cells and the signaling pathways that sense the status of different types of stress and induce autophagic for cell survival and homeostasis are presented.
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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
TL;DR: In light of the recent advances in understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, the exciting therapeutic opportunities for targeting this pathway to treat these diseases are discussed.
References
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TSC2 mediates cellular energy response to control cell growth and survival.
TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
Journal ArticleDOI
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Do Hyung Kim,Dos D. Sarbassov,Siraj M. Ali,Jessie E. King,Robert R. Latek,Hediye Erdjument-Bromage,Paul Tempst,David M. Sabatini +7 more
TL;DR: It is reported that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels.
Journal ArticleDOI
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
TL;DR: It is shown that TSC1–TSC2 inhibits the p70 ribosomal protein S6 kinase 1 and activates the eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translational initiation) and these functions are mediated by inhibition of the mammalian target of rapamycin (mTOR).
Journal ArticleDOI
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Dos D. Sarbassov,Siraj M. Ali,Do Hyung Kim,David A. Guertin,Robert R. Latek,Hediye Erdjument-Bromage,Paul Tempst,David M. Sabatini +7 more
TL;DR: It is found that the rictor-mTOR complex modulates the phosphorylation of Protein Kinase C alpha (PKCalpha) and the actin cytoskeleton, suggesting that this aspect of TOR signaling is conserved between yeast and mammals.
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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Xueping Qu,Jie Yu,Govind Bhagat,Norihiko Furuya,Hanina Hibshoosh,Andrea B. Troxel,Jeffrey M. Rosen,Eeva-Liisa Eskelinen,Noboru Mizushima,Yoshinori Ohsumi,Giorgio Cattoretti,Beth Levine +11 more
TL;DR: It is shown that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus-induced premalignant lesions, providing genetic evidence that autophagy is a novel mechanism of cell-growth control and tumor suppression.