Christian Sell

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Results demonstrate that signaling via the IGF-I receptor is an indispensable component of the SV40 transformation pathway, and is further supported from the results of antisense RNA experiments with tumor cell lines showing that interference with the function of the IGF -I receptor has a profound effect on anchorage-independent growth, even under conditions that only modestly affect growth in monolayers.

TL;DR: Reintroduction into R- cells (or their derivatives) of a plasmid expressing the human insulin-like growth factor I receptor RNA and protein restores their ability to grow with purified growth factors or in soft agar.

TL;DR: It is proposed that an accumulation of p16INK4a-positive senescent astrocytes may link increased age and increased risk for sporadic AD and a number of inflammatory cytokines including interleukin-6 (IL-6), which seems to be regulated by p38MAPK.