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Open AccessJournal ArticleDOI

Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation.

John Kim, +3 more
- 04 Jan 2002 - 
- Vol. 277, Iss: 1, pp 763-773
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TLDR
This study characterized the putative compartment from which both autophagosomes and the analogous Cvt vesicles may originate and identified a perivacuolar membrane as the resident compartment for both the Apg-Cvt9 signaling complex, which mediates the switching between autophagic and Cvt transport, and the autophagy/Cvt-specific phosphatidylinositol 3-kinase complex.
About: 
This article is published in Journal of Biological Chemistry.The article was published on 2002-01-04 and is currently open access. It has received 301 citations till now. The article focuses on the topics: CVT vesicle & Cytoplasm-to-vacuole targeting.

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Citations
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy

Beth Levine, +1 more
- 01 Apr 2004 - 
TL;DR: This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Daniel J. Klionsky, +235 more
- 16 Feb 2008 - 
TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Journal ArticleDOI

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Xueping Qu, +11 more
- 15 Dec 2003 - 
TL;DR: It is shown that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus-induced premalignant lesions, providing genetic evidence that autophagy is a novel mechanism of cell-growth control and tumor suppression.
References
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Journal ArticleDOI

Autophagy as a Regulated Pathway of Cellular Degradation

Daniel J. Klionsky, +1 more
- 01 Dec 2000 - 
TL;DR: The core protein machinery that is necessary to drive formation and consumption of intermediates in the macroautophagy pathway includes a ubiquitin-like protein conjugation system and a protein complex that directs membrane docking and fusion at the lysosome or vacuole.
Journal ArticleDOI

Rab proteins as membrane organizers

Marino Zerial, +1 more
- 01 Feb 2001 - 
TL;DR: Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport.
Journal ArticleDOI

Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Xiao Huan Liang, +6 more
- 09 Dec 1999 - 
TL;DR: It is shown that beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma, suggesting that decreased expression of Autophagy proteins may contribute to the development or progression of breast and other human malignancies.
Journal ArticleDOI

A ubiquitin-like system mediates protein lipidation

Yoshinobu Ichimura, +15 more
- 23 Nov 2000 - 
TL;DR: A new mode of protein lipidation is reported, in which Apg8 is covalently conjugated to phosphatidylethanolamine through an amide bond between the C-terminal glycine and the amino group of phosph atidyleanolamine, mediated by a ubiquitination-like system.
Journal ArticleDOI

Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.

Miki Tsukada, +1 more
- 25 Oct 1993 - 
TL;DR: The results on the apg mutants suggest that autophagy via autophagic bodies is indispensable for protein degradation in the vacuoles under starvation conditions, and that at least 15 APG genes are involved inAutophagy in yeast.
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