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Fabio Di Domenico

Researcher at Sapienza University of Rome

Publications -  117
Citations -  11953

Fabio Di Domenico is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Oxidative stress & Alzheimer's disease. The author has an hindex of 44, co-authored 107 publications receiving 9793 citations. Previous affiliations of Fabio Di Domenico include University of Kentucky.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain.

D. Allan Butterfield, +2 more
- 01 Sep 2014 - 
TL;DR: Molecular aspects and the pharmacological approaches from both preclinical and clinical data interpreted from the point of view of oxidative stress are provided with the aim of highlighting progresses in this field.
Journal ArticleDOI

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

Antonella Tramutola, +7 more
- 01 Jun 2015 - 
TL;DR: The findings suggest that the alteration of mTOR signaling and autophagy occurs at early stages of AD, and hint at a link between Aβ and the PI3K/Akt/mTOR axis and provide further insights into the relationship between AD pathology and insulin resistance.
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Aberrant insulin signaling in Alzheimer's disease: current knowledge.

Gaurav Bedse, +3 more
- 16 Jun 2015 - 
TL;DR: Considering that insulin mitigates beta-amyloid deposition and phosphorylation of tau, pharmacological strategies restoring brain insulin signaling, such as intranasal delivery of insulin, could have significant therapeutic potential in AD treatment.