Jie Fan

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: PMN NAD(P)H oxidase activation, induced by HS/R and as mediated by HMGB1/TLR4 signaling, is an important mechanism responsible for PMN-mediated inflammation and organ injury after hemorrhage.

TL;DR: An overview of the major types of cell death related to inflammation is provided and modified cell death pathways are likely to be a logical therapeutic target for inflammatory diseases.

TL;DR: It is demonstrated that HMGB1, acting through RAGE and dynamin-dependent signaling, initiatesHMGB1endocytosis, which in turn induces cell pyroptosis, shedding light on the regulatory role of ligand-receptor internalization in directing cell fate, which may have an important role in the progress of inflammation following infection and injury.