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Open AccessJournal ArticleDOI

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

Jun Hee Lee, +24 more
- 05 Sep 2012 - 
- Vol. 16, Iss: 3, pp 311-321
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TLDR
Sestrin2--encoded by the Sesn2 locus, whose expression is induced upon hypernutrition--maintains metabolic homeostasis in liver of obese mice, demonstrating an important homeostatic function for the stress-inducible Sestrin protein family in the control of mammalian lipid and glucose metabolism.
About: 
This article is published in Cell Metabolism.The article was published on 2012-09-05 and is currently open access. It has received 242 citations till now. The article focuses on the topics: Insulin resistance & AMPK.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.

Gommaar D'Hulst, +14 more
- 10 Jan 2020 - 
TL;DR: The authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner and prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucines.
Journal Article

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]

Sung Hee Um, +9 more
- 01 Jan 2004 - 
TL;DR: In this article, S6K1-deficient mice are protected against obesity owing to enhanced β-oxidation, but on a high fat diet, levels of glucose and free fatty acids still rise in S6k1-dependent mice, resulting in insulin receptor desensitization.
Journal ArticleDOI

Oxidative stress and autophagy: the clash between damage and metabolic needs

Giuseppe Filomeni, +2 more
- 01 Mar 2015 - 
TL;DR: This review aims at providing novel insight into the regulatory pathways of autophagy in response to glucose and amino acid deprivation, as well as their tight interconnection with metabolic networks and redox homeostasis.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
References
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Journal ArticleDOI

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.

Eugenia E. Calle, +3 more
- 24 Apr 2003 - 
TL;DR: Current patterns of overweight and obesity in the United States could account for 14 percent of all deaths from cancer in men and 20 percent of those in women, and increased body weight was associated with increased death rates for all cancers combined and for cancers at multiple specific sites.
Journal ArticleDOI

AKT/PKB signaling: navigating downstream.

Brendan D. Manning, +1 more
- 29 Jun 2007 - 
TL;DR: Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.
Journal ArticleDOI

Nonalcoholic fatty liver disease.

Paul Angulo
- 18 Apr 2002 - 
TL;DR: Nonalcoholic fatty liver disease is associated with an increased risk of all-cause death, probably because of complications of insulin resistance such as vascular disease, as well as due to cirrhosis and hepatocellular carcinoma, which occurs in a minority of patients.
Journal ArticleDOI

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima, +1 more
- 11 Nov 2011 - 
TL;DR: It is explored how recent mouse models in combination with advances in human genetics are providing key insights into how the impairment or activation of autophagy contributes to pathogenesis of diverse diseases, from neurodegenerative diseases such as Parkinson disease to inflammatory disorders such as Crohn disease.
Journal ArticleDOI

mTOR: from growth signal integration to cancer, diabetes and ageing

Roberto Zoncu, +2 more
- 01 Jan 2011 - 
TL;DR: Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt.
Related Papers (5)

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Andrei V. Budanov, +1 more
- 08 Aug 2008 - 

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Jun Hee Lee, +10 more
- 05 Mar 2010 - 

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

Andrei V. Budanov, +6 more
- 23 Apr 2004 - 

Sestrins orchestrate cellular metabolism to attenuate aging

Jun Hee Lee, +2 more
- 03 Dec 2013 - 

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

Soo Han Bae, +8 more
- 08 Jan 2013 -