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Open AccessJournal ArticleDOI

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

Yuchen Feng, +2 more
- 01 Jun 2015 - 
- Vol. 25, Iss: 6, pp 354-363
TLDR
The current state of knowledge concerning transcriptional, post-transcriptional, and post- translational regulation of autophagy in yeast and mammals is focused on.
About: 
This article is published in Trends in Cell Biology.The article was published on 2015-06-01 and is currently open access. It has received 285 citations till now. The article focuses on the topics: BAG3 & Autophagy.

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Citations
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

TFEB at a glance.

Gennaro Napolitano, +1 more
- 01 Jul 2016 - 
TL;DR: The roles of TFEB as a regulator of lysosomal biogenesis and intracellular clearance, and its involvement in human diseases are discussed.
Journal ArticleDOI

Autophagy: machinery and regulation.

Zhangyuan Yin, +2 more
- 01 Dec 2016 - 
TL;DR: In this review, the physiological roles, molecular mechanism, regulatory network, and pathophysiological roles of autophagy are summarized.
Journal ArticleDOI

An Autophagic Flux Probe that Releases an Internal Control

Takeshi Kaizuka, +9 more
- 17 Nov 2016 - 
TL;DR: The GFP- LC3-RFP-LC3ΔG probe is a simple and quantitative method to evaluate autophagic flux in cultured cells and whole organisms, and re-evaluated previously reported autophagy-modulating compounds, performed a high-throughput screen of an approved drug library, and identified autophile modulators.
References
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Journal ArticleDOI

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Rosalind C. Lee, +2 more
- 03 Dec 1993 - 
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI

MicroRNAs: small RNAs with a big role in gene regulation

Lin He, +1 more
- 01 Jul 2004 - 
TL;DR: Two founding members of the microRNA family were originally identified in Caenorhabditis elegans as genes that were required for the timed regulation of developmental events and indicate the existence of multiple RISCs that carry out related but specific biological functions.
Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Bruce Wightman, +2 more
- 03 Dec 1993 - 
TL;DR: It is demonstrated that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple elements in the lin-14 3'UTR that are regulated by the heterochronic gene Lin-4.
Journal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more
- 26 Nov 2003 - 
TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
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